I think it depends on whether you want to commit to long term lockpickage or short term.
Long term : Open every chest you find, this should increase your ranks in treasure hunter and lucky and therefore increase your retention rates. Check wiki for when lockpicks become more effective than keys in their respective areas.
Short term : Short term lockpicks aren't really effective. It will be more effective to buy the keys for the area, the key price will correspond to how high end the items are likely to be ie obs keys = chances at decent stuff ascalonian keys = toy soldier items. Only real reason to use keys short term is if you are too lazy to buy lockpicks and have excess amounts of money.
So if your in it for titles/long term gain use lockpicks on everything, if you only want the fun of opening a chest once in a while go with the key of the area.
Last edited by Maccarelly; Nov 17, 2008 at 05:18 PM // 17:18..
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